moscot.problems.cross_modality.TranslationProblem.solve

TranslationProblem.solve(alpha=1.0, epsilon=0.01, tau_a=1.0, tau_b=1.0, rank=-1, scale_cost='mean', batch_size=None, stage=('prepared', 'solved'), initializer=None, initializer_kwargs=mappingproxy({}), jit=True, min_iterations=None, max_iterations=None, threshold=0.001, linear_solver_kwargs=mappingproxy({}), device=None, **kwargs)

Solve the translation problem.

See also

• See Translating multiomics single-cell data on how to solve the TranslationProblem.

Parameters:

• alpha (Optional[float]) – Parameter in \((0, 1]\) that interpolates between the quadratic term and the linear term. \(\alpha = 1\) corresponds to the pure Gromov-Wasserstein problem while \(\alpha \to 0\) corresponds to the pure linear problem.

• epsilon (float) – Entropic regularization.

• tau_a (float) – Parameter in \((0, 1]\) that defines how much unbalanced is the problem on the source marginals. If \(1\), the problem is balanced.

• tau_b (float) – Parameter in \((0, 1]\) that defines how much unbalanced is the problem on the target marginals. If \(1\), the problem is balanced.

• rank (int) – Rank of the low-rank OT solver [Scetbon et al., 2021]. If \(-1\), full-rank solver [Peyré et al., 2016] is used.

• scale_cost (Union[float, Literal['mean', 'max_cost', 'max_bound', 'max_norm', 'median']]) – How to re-scale the cost matrices. If a float, the cost matrices will be re-scaled as \(\frac{\text{cost}}{\text{scale_cost}}\).

• batch_size (Optional[int]) – Number of rows/columns of the cost matrix to materialize during the solver iterations. Larger value will require more memory.

• stage (Union[Literal['prepared', 'solved'], Tuple[Literal['prepared', 'solved'], ...]]) – Stage by which to filter the problems to be solved.

• initializer (Optional[Literal['random', 'rank2', 'k-means', 'generalized-k-means']]) – How to initialize the solution. If None, 'default' will be used for a full-rank solver and 'rank2' for a low-rank solver.

• initializer_kwargs (Mapping[str, Any]) – Keyword arguments for the initializer.

• jit (bool) – Whether to jit() the underlying ott solver.

• min_iterations (Optional[int]) – Minimum number of (fused) GW iterations.

• max_iterations (Optional[int]) – Maximum number of (fused) GW iterations.

• threshold (float) – Convergence threshold of the GW solver.

• linear_solver_kwargs (Mapping[str, Any]) – Keyword arguments for the inner linear problem solver.

• device (Optional[Literal['cpu', 'gpu', 'tpu']]) – Transfer the solution to a different device, see to(). If None, keep the output on the original device.

• **kwargs (Any) – The description is missing.

Return type:

TranslationProblem[TypeVar(K, bound= Hashable)]

Returns:

: Returns self and updates the following fields:

• solutions - the OT solutions for each subproblem.

• stage - set to 'solved'.