moscot.datasets.pancreas_multiome

moscot.datasets.pancreas_multiome(rna_only, path='~/.cache/moscot/pancreas_multiome.h5mu', force_download=True, **kwargs)[source]

Pancreatic endocrinogenesis dataset published with the moscot manuscript [Klein et al., 2025].

The dataset contains paired scRNA-seq and scATAC-seq data of pancreatic cells at embryonic days 14.5, 15.5, and 16.5. The data was preprocessed and filtered as described in the manuscript, the raw data and the full processed data are available via GEO accession code GSE275562.

Parameters:

  • rna_only (bool) – Only load the RNA data, resulting in a smaller file.

  • path (Union[PathLike, str]) – Path where to save the file.

  • force_download (bool) – Whether to force-download the data.

  • kwargs (Any) – Keyword arguments for anndata.io.read_h5ad() if rna_only, else for mudata.read().

Return type:

Union[MuData, AnnData]

Returns:

: mudata.MuData object with RNA and ATAC data if rna_only, else anndata.AnnData with RNA only.